Physicochemical Study on Human Chorionic Gonadotropin

Physicochemical characterization of native and asialo human chorionic gonadotropin.

Human chorionic gonadotropin (HCG) was desialized by treatment with neuraminidase to yield asialo-HCG, and comparative physicochemical studies were carried out on HCG and asialo-HCG. The E:trn value at 276 nm was 5.47 for HCG and 5.72 for asialo-HCG. Intrinsic viscosities of HCG and asialo-HCG at near isoionic point were estimated to be 3.4 and 3.2 ml per g, respectively. HCG had an isoionic po...

Human Chorionic Gonadotropin

A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...

Human chorionic gonadotropin (hCG) versus magnesium sulfate to arrest preterm

Introduction: Considering the high incidence of preterm labor and its known complications, and that human myometrium contains receptors for human chronic gonadotropin (hCG) and that hCG can inhibit myometrial contractions on vitro, made me study treating effects of hCG on preterm labor. This clinical trial study was carried out to compare the effect of hCG, and magnesium sulfate (mgso4) on pre...

Quantification of Human Chorionic Gonadotropin by Bovine Serum Albumin Nanoparticles

Background and Aims: Some nanoparticles can be used in immunoassays to increase sensitivity. This study aimed to evaluate a novel nano-immunoassay based on bovine serum albumin nanoparticles (BSA NPs). Materials and methods: At first, the nanostructure was synthesized, and then applied as a tag in the nano-immunoassay. Then the concentration of β-subunit of human chorionic gonadotropin ...

Immunologic and Biologic Study of Human Chorionic Gonadotropin.